I suspect that this is because the grid from your LF simulation does not match the grid that you use in your isotropic and anisotropic simulations.
The isotropic simulation runs fine because it does not use your cache file.
The anisotropic simulation has stored those conductivity values expecting a specific grid.
Try right clicking on the grid settings folder in the simulation from which you are creating your anisotropy tensor, select "Copy Grid Configuration", then "Paste Grid Configuration" on the anisotropic simulation.
If you want to include features in your anisotropic simulation that you don't don't want to have simulated in your initial LF simulation, you can still include include objects in your initial simulation so that they are considered for the gridding without assigning them material properties, using them as a boundary condition or voxeling them. Just drag the object directly into the grid settings folder. That way your grid can always match.